Characterization of bone marrow mesenchymal stromal cells in aplastic anaemia
نویسندگان
چکیده
منابع مشابه
Massive apoptosis of bone marrow cells in aplastic anaemia.
The pathogenesis of aplastic anaemia (AA) is still incompletely understood. Bone marrow (BM) hypoplasia is a hallmark of AA and one of the considered mechanisms of hypoplasia is an increased apoptosis of haematopoietic progenitors. However, definitive evidence supporting this is largely lacking (Ismail et al, 2001). We have studied in situ apoptosis of BM mononuclear cells (BMMNCs) in the BM bi...
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Eighteen patients, twelve men and six women, with aplastic anemia underwent allogenic bone marrow transplantation (BMT) from HLA-matched siblings during the period of 1990 to 1996. The conditioning regimen was cyclophosphamide with or without busulfan, depending on the cause of aplasia. Antilymphocyte globulin (ALG) and cyclosporine were used for rejection and acute GVHD prophylaxis, respe...
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In the bone marrow, there are certain populations of stem cell sources with the capacity to differentiate into several different types of cells. Ideally, cell transplants would be readily obtainable, easy to expand and bank, and capable of surviving for sufficient periods of time. Bone marrow mesenchymal stem cells (BM-MSCs) possess all of these characteristics. One of the most important benefi...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2015
ISSN: 0007-1048
DOI: 10.1111/bjh.13364